منابع مشابه
Regulation of transcription by bent DNA through chromatin structure
A class of bent DNA is present in the genomic DNA of higher eukaryotes as a repeating unit (Kiyama, R., Gene Ther. Mol. Biol. 1, 641-647, 1998). This bent DNA appears once every 680 bp on average, and often shows periodicity, suggesting biological significance. By having a higher affinity for histone core particles, it has a role in designating a key nucleosome, which initiates nucleosome align...
متن کاملGapped DNA is anisotropically bent.
Ionizing radiation damages DNA in several ways, including through formation of a single-nucleoside gap in one DNA strand. We have developed a two-dimensional gel electrophoresis method to investigate the effect of a strand gap on DNA structure. We generate a library of gapped DNA molecules by treating a DNA restriction fragment with the hydroxyl radical, generated by the reaction of Fe(II) EDTA...
متن کاملIn vitro preferential topoisomerization of bent DNA.
The steps of the topoisomerization reaction by calf thymus DNA topoisomerase I on a DNA domain containing an intrinsically bent DNA sequence have been analyzed. High preferentiality of binding, cleavage and topoisomerization on the bent segment relative to the rest of the DNA domain was observed. These studies show the importance of the local DNA conformation in the reaction of eukaryotic DNA t...
متن کاملIntrinsically bent DNA in replication origins and gene promoters.
Intrinsically bent DNA is an alternative conformation of the DNA molecule caused by the presence of dA/dT tracts, 2 to 6 bp long, in a helical turn phase DNA or with multiple intervals of 10 to 11 bp. Other than flexibility, intrinsic bending sites induce DNA curvature in particular chromosome regions such as replication origins and promoters. Intrinsically bent DNA sites are important in initi...
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ژورنال
عنوان ژورنال: Nature
سال: 1986
ISSN: 0028-0836,1476-4687
DOI: 10.1038/320487a0